2-巯基-4-氨基-7H-吡咯[2,3-d]嘧啶合成路线 （共 4 条）
反应条件
1: potassium tert-butylate / ethanol / 0 °C / |Reflux 2: hydrogenchloride / water / 1.17 h / 50 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 62, # 1 p. 25 - 34
反应条件
1: 99.1 percent / aq. KOH; hydrogen peroxide / 5 - 15 °C 2: 84 percent / sulfuric acid / 5.5 h / 20 - 75 °C 3: 85.6 percent / N,N-dimethylacetamide; N,N-diisopropylethylamine View Scheme
参考文献
Bio, Matthew M.; Xu, Feng; Waters, Marjorie; Williams, J. Michael; Savary, Kimberly A.; Cowden, Cameron J.; Yang, Chunhua; Buck, Elizabeth; Song, Zhiguo J.; Tschaen, David M.; Volante; Reamer, Robert A.; Grabowski, Edward J. J.
Journal of Organic Chemistry, 2004 , vol. 69, # 19 p. 6257 - 6266
反应条件
potassium hydroxide; dihydrogen peroxide T=5 - 15°C;
参考文献
Bio, Matthew M.; Xu, Feng; Waters, Marjorie; Williams, J. Michael; Savary, Kimberly A.; Cowden, Cameron J.; Yang, Chunhua; Buck, Elizabeth; Song, Zhiguo J.; Tschaen, David M.; Volante; Reamer, Robert A.; Grabowski, Edward J. J.
Journal of Organic Chemistry, 2004 , vol. 69, # 19 p. 6257 - 6266
反应条件
1: in water Reflux; 2: With sodium hydroxide in water T=50°C;
参考文献
Jung, Myung-Ho; Kim, Hwan; Choi, Won-Kyoung; El-Gamal, Mohammed I.; Park, Jin-Hun; Yoo, Kyung Ho; Sim, Tae Bo; Lee, So Ha; Baek, Daejin; Hah, Jung-Mi; Cho, Jung-Hyuck; Oh, Chang-Hyun
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6538 - 6543
