2-氨基-5-溴-4-甲基吡啶合成路线 （共 25 条）
反应条件
1.1: trifluoroacetic acid; N-iodo-succinimide / acetic acid / 2.5 h / 20 °C 1.2: Cooling 2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere 3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 °C View Scheme
参考文献
Daiichi Sankyo Company, Limited
Patent: US2011/82138 A1, 2011 ;
US 20110082138 A1
反应条件
in ethanol; water T=100°C; 16 h; Inert atmosphere;
参考文献
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; DURAISWAMY, Athisayamani, Jeyaraj; CHENNAMANENI, Lohitha, Rao
Patent: WO2013/147711 A1, 2013 ;
Location in patent: Page/Page column 207 ;
反应条件
1.1: isopropyl alcohol / 3 h / 80 °C 1.2: 50 °C 2.1: trifluoroacetic anhydride / tetrahydrofuran / 3.25 h / 0 - 20 °C View Scheme
参考文献
CalciMedica, Inc.
Patent: US2011/263612 A1, 2011 ;
US 20110263612 A1
反应条件
sulfuric acid; nitric acid
参考文献
Daiichi Sankyo Company, Limited
Patent: US2011/82138 A1, 2011 ;
Location in patent: Page/Page column 21 ;
US 20110082138 A1
参考文献
Dunn; Norrie
Advanced Synthesis and Catalysis, 1996 , vol. 338, # 7 p. 663 - 666
反应条件
1.1: sulfuric acid; nitric acid / -10 - 22 °C 2.1: sulfuric acid / 2 h / 22 °C 2.2: 22 °C 3.1: hydrogenchloride; tin(ll) chloride / water / 0 - 100 °C 4.1: 1 h / Erfllectrochemical reaction 5.1: 10 palladium on activated carbon; platinum(IV) oxide; hydrogen; sodium hydroxide / water / 0.5 h / 2585.81 Torr View Scheme
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
sodium nitrite in sulfuric acid; water
参考文献
SmithKline Beecham p.l.c.
Patent: US5536745 A1, 1996 ;
反应条件
1: in isobutyramide T=170°C; 24 h; Inert atmosphere; 2: With ethylenediamine in isobutyramide; water 0.25 h;
参考文献
NOVARTIS AG; BETSCHART, Claudia; COTESTA, Simona; HINTERMANN, Samuel; WAGNER, Juergen; ROY, Bernard, Lucien; GERSPACHER, Marc; VON MATT, Anette; BEHNKE, Dirk
Patent: WO2011/73316 A1, 2011 ;
Location in patent: Page/Page column 65 ;
WO 2011/073316 A1
反应条件
in N,N-dimethyl-formamide 20 h; Heating;
参考文献
Dunn; Norrie
Advanced Synthesis and Catalysis, 1996 , vol. 338, # 7 p. 663 - 666
反应条件
dimethylammonium 2,4-dichlorophenoxyacetate; CuCN
参考文献
Salvati, Mark E.; Balog, James Aaron; Pickering, Dacia A.; Giese, Soren; Fura, Aberra; Li, Wenying; Patel, Ramesh N.; Hanson, Ronald L.; Mitt, Toomas; Roberge, Jacques Y.; Corte, James R.; Spergel, Steven H.; Rampulla, Richard A.; Misra, Raj N.; Xiao, Hai-Yun
Patent: US2004/77605 A1, 2004 ;
US 20040077605 A1
