N-甲基-4-硝基苯乙酰胺合成路线 （共 11 条）
反应条件
N-ethyl-N,N-diisopropylamine; HATU in dichloromethane T=0 - 20°C; 16 h;
参考文献
WO2011/140009 A1, ;
Page/Page column 99; 100 ;
反应条件
4-methylpyridine 1-oxide; Wilkinson's catalyst in acetonitrile T=50°C; Staudinger Ketene Cycloaddition; 4 h; Inert atmosphere; diastereoselective reaction;
参考文献
Organic Letters, , vol. 16, # 9 p. 2482 - 2485
反应条件
potassium carbonate in tetrahydrofuran; water T=50°C; 12 h;
参考文献
Journal of Pharmaceutical Sciences, , vol. 76, # 1 p. 18 - 20
反应条件
benzoyl chloride man fuegt Methylamin in Wasser und Natronlauge hinzu;
参考文献
Journal of the Chemical Society, , vol. 79, p. 1355
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 16, p. 35
反应条件
1: KOH-solution 2: concentrated nitric acid View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 16, p. 35
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 16, p. 35
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2585.7 Torr; Yield given;
参考文献
Clark; Davenport
Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 1 p. 18 - 20
反应条件
1: Eaton’s reagent / 80 °C 2: palladium 10 on activated carbon; hydrogen / ethanol; ethyl acetate / 2 h / 1034.32 Torr View Scheme
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
反应条件
phosphorous pentoxide in methanesulfonic acid T=80°C; 1 h;
参考文献
Yang, Qiang; Ulysse, Luckner G.; McLaws, Mark D.; Keefe, Daniel K.; Haney, Brian P.; Zha, Congxiang; Guzzo, Peter R.; Liu, Shuang
Organic Process Research and Development, 2012 , vol. 16, # 3 p. 499 - 506
