Boc-3-(3-吡啶基)-D-丙氨酸合成路线 （共 6 条）
反应条件
in water; tert-butyl alcohol 3 h;
参考文献
Rivier, Jean E.; Porter, John; Rivier, Catherine L.; Perrin, Marylin; Corrigan, Anne; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1846 - 1851
反应条件
1: AC2O; ACONa / 3 h / 100 °C 2: 37.55 g / H2O / acetone / 6 h / Heating 3: 79 percent / H2 / Pd/C / H2O / 8 h / 20 °C 4: 100 percent / aq. NH3; D-aminoacylase amano / 74 h / 35 °C 5: 65 percent / aq.NaOH / dioxane / 15 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7592 - 7595
反应条件
1: 37.55 g / H2O / acetone / 6 h / Heating 2: 79 percent / H2 / Pd/C / H2O / 8 h / 20 °C 3: 100 percent / aq. NH3; D-aminoacylase amano / 74 h / 35 °C 4: 65 percent / aq.NaOH / dioxane / 15 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7592 - 7595
反应条件
1: 79 percent / H2 / Pd/C / H2O / 8 h / 20 °C 2: 100 percent / aq. NH3; D-aminoacylase amano / 74 h / 35 °C 3: 65 percent / aq.NaOH / dioxane / 15 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7592 - 7595
反应条件
1: 100 percent / aq. NH3; D-aminoacylase amano / 74 h / 35 °C 2: 65 percent / aq.NaOH / dioxane / 15 h / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7592 - 7595
参考文献
Rivier, Jean; Porter, John; Hoeger, Carl; Theobald, Paula; Craig, A. Grey; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4270 - 4278
