4-溴-2-碘-1-甲氧基苯合成路线 （共 8 条）
反应条件
1: in tetrahydrofuran; hexane; pentane
T=-30°C; 20 h;
2: With iodine in tetrahydrofuran; hexane; pentane
T=20°C; 1 h; Further stages.;
参考文献
Uchiyama, Masanobu; Kobayashi, Yuri; Furuyama, Taniyuki; Nakamura, Shinji; Kajihara, Yumiko; Miyoshi, Tomoko; Sakamoto, Takao; Kondo, Yoshinori; Morokuma, Keiji
Journal of the American Chemical Society, 2008 , vol. 130, # 2 p. 472 - 480
反应条件
potassium carbonate in hexadeuterioacetone
参考文献
Pfizer Limited; Omoto, Kiyoyuki; Owen, Robert McKenzie; Pryde, David Cameron; Watson, Christine Ann Louise; Takeuchi, Mifune
Patent: US2014/171435 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
iodine; isopropylmagnesium chloride
1) THF, 40 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Nishiyama, Hisao; Isaka, Kojun; Itoh, Kenji; Ohno, Kiyotaka; Nagase, Hiroshi; et al.
Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 407 - 410
反应条件
1: 1) i-PrMgCl, 2) H2O / 1) THF, 40 deg C, 1 h; 2) 0 deg C
2: 1) i-PrMgCl, 2) I2 / 1) THF, 40 deg C, 3 h
View Scheme
参考文献
Nishiyama, Hisao; Isaka, Kojun; Itoh, Kenji; Ohno, Kiyotaka; Nagase, Hiroshi; et al.
Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 407 - 410
反应条件
iodine cloride in dichloromethane
T=25°C; 45 h; Product distribution;
参考文献
Hubig, S. M.; Jung, W.; Kochi, J. K.
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6233 - 6244
参考文献
Hirtz
Chemische Berichte, 1896 , vol. 29, p. 1410
反应条件
1: Diazotization.Zersetzung des Diazoniumsalzes durch Jodkalium
2: chloroform; bromine
View Scheme
参考文献
Hirtz
Chemische Berichte, 1896 , vol. 29, p. 1410
参考文献
Hirtz
Chemische Berichte, 1896 , vol. 29, p. 1410
