N-Boc-2-哌啶甲酸合成路线 （共 35 条）
反应条件
tetreamethyl ammonium hydroxide in acetonitrile 72 h; Ambient temperature;
参考文献
Khalil, Ehab M.; Subasinghe, Nalin L.; Johnson, Rodney L.
Tetrahedron Letters, 1996 , vol. 37, # 20 p. 3441 - 3444
反应条件
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide in acetonitrile T=20°C; 3 h;
参考文献
Schmidt, Andrea-Katharina C.; Stark, Christian B. W.
Organic Letters, 2011 , vol. 13, # 16 p. 4164 - 4167
反应条件
sodium hydrogencarbonate; triethylamine in acetone
反应条件
triethylamine in water; acetone
参考文献
Ho, Bin; Venkatarangan, Prabha M.; Cruse, Sharon F.; Hinko, Christine N.; Andersen, Peter H.; Crider, Albert M.; Adloo, Ahmad A.; Roane, David S.; Stables, James P.
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 1 p. 23 - 31
反应条件
1.1: 79 percent / DMAP / acetonitrile 2.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3.1: 86 percent / p-TsOH / toluene / 0.33 h 4.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 4.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 5.1: (S)-BINAP; Rh(I); H2 / methanol View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 79 percent / DMAP / acetonitrile 2.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 3.1: 86 percent / p-TsOH / toluene / 0.33 h 4.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 4.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 5.1: (S)-BINAP; Rh(I); H2 / methanol View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
triethylamine in 1,4-dioxane; water 2 h; Ambient temperature;
参考文献
Hofmann, Thomas; Schieberle, Peter
Journal of Agricultural and Food Chemistry, 1998 , vol. 46, # 2 p. 616 - 619
反应条件
1: 30percent hydrogen peroxide / acetic acid / 24 h / Heating 2: dimethylcarbamyl chloride / CH2Cl2 / 24 h / Ambient temperature 3: 71 percent / 6 N HCl / 24 h / Heating 4: hydrogen / platinum oxide / ethanol; H2O / 24 h / 60 °C / 3102.9 Torr 5: 74 percent / 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 2 p. 738 - 741
反应条件
1: dimethylcarbamyl chloride / CH2Cl2 / 24 h / Ambient temperature 2: 71 percent / 6 N HCl / 24 h / Heating 3: hydrogen / platinum oxide / ethanol; H2O / 24 h / 60 °C / 3102.9 Torr 4: 74 percent / 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 2 p. 738 - 741
反应条件
1: 100 percent / hydrogen / platinum oxide / H2O / 5 h / 60 °C / 3102.9 Torr 2: 74 percent / 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 2 p. 738 - 741
