N-Boc-2-哌啶甲酸合成路线 （共 35 条）
反应条件
1: hydrogen / platinum oxide / ethanol; H2O / 24 h / 60 °C / 3102.9 Torr 2: 74 percent / 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 2 p. 738 - 741
反应条件
1: 71 percent / 6 N HCl / 24 h / Heating 2: hydrogen / platinum oxide / ethanol; H2O / 24 h / 60 °C / 3102.9 Torr 3: 74 percent / 2 N NaOH / 2-methyl-propan-2-ol / 24 h / Ambient temperature; pH at 9.5 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 2 p. 738 - 741
反应条件
hydrogen; rhodium cation; (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl in methanol Reduction;
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 89 percent / NaH / tetrahydrofuran / 6 h / 20 °C 2.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 5 h / -78 °C 2.2: 80 percent / tetrahydrofuran; cyclohexane / 0.08 h / -78 °C 3.1: (S)-BINAP; Rh(I); H2 / methanol View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 1.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 2.1: (S)-BINAP; Rh(I); H2 / methanol View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 86 percent / p-TsOH / toluene / 0.33 h 2.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 2.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 3.1: (S)-BINAP; Rh(I); H2 / methanol View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: 94 percent / DIBALH / CH2Cl2; hexane / 3 h / -78 °C 2.1: 86 percent / p-TsOH / toluene / 0.33 h 3.1: n-BuLi; TMEDA / tetrahydrofuran; hexane / -65 - -30 °C 3.2: 52 percent / tetrahydrofuran; hexane / 0.08 h / -78 °C 4.1: (S)-BINAP; Rh(I); H2 / methanol View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
反应条件
1.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 5 h / -78 °C 1.2: 80 percent / tetrahydrofuran; cyclohexane / 0.08 h / -78 °C 2.1: (S)-BINAP; Rh(I); H2 / methanol View Scheme
参考文献
Organic letters, , vol. 2, # 2 p. 155 - 158
参考文献
Paruszewski; Strupinska; Stables; Swiader; Czuczwar; Kleinrok; Turski
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 5 p. 629 - 631
反应条件
1: NaHCO3 2: 59 percent / LDA/THF / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 7 p. 879 - 880
