N-Boc-2-哌啶甲酸合成路线 （共 35 条）
反应条件
1: 87 percent / Ph3P / acetonitrile / Heating 2: diethyl ether View Scheme
参考文献
Journal of Agricultural and Food Chemistry, , vol. 46, # 2 p. 616 - 619
反应条件
1: 1) N-methylmorpholine, isobutyl chloroformate / 1) THF, 0 deg C to 5 deg C, 2) THF, r.t. 2: HCl / CH2Cl2 / 0 - 5 °C View Scheme
参考文献
Ho, Bin; Venkatarangan, Prabha M.; Cruse, Sharon F.; Hinko, Christine N.; Andersen, Peter H.; Crider, Albert M.; Adloo, Ahmad A.; Roane, David S.; Stables, James P.
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 1 p. 23 - 31
反应条件
in methanol; hexanes; toluene
T=0 - 20°C; Inert atmosphere; optical yield given as percent ee;
参考文献
Stead, Darren; Carbone, Giorgio; O'Brien, Peter; Campos, Kevin R.; Coldham, Iain; Sanderson, Adam
Journal of the American Chemical Society, 2010 , vol. 132, # 21 p. 7260 - 7261
反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h
1.2: 90 percent / tetrahydrofuran; hexane / 24 h
2.1: 55 percent / NaIO4 / OsO4 / tetrahydrofuran; H2O
View Scheme
参考文献
Somu, Ravindranadh V.; Johnson, Rodney L.
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5954 - 5963
反应条件
1: 60 percent / ethyldiisopropylamine; PyBroP / CH2Cl2 / 12 h / 20 °C
2: 44 percent / HCl / methanol; dioxane; H2O / 20 h / Heating
View Scheme
参考文献
Charton, Julie; Girault-Mizzi, Sophie; Debreu-Fontaine, Marie-Ange; Foufelle, Fabienne; Hainault, Isabelle; Bizot-Espiard, Jean-Guy; Caignard, Daniel-Henri; Sergheraert, Christian
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 13 p. 4490 - 4518
