1: 1.) LDA / 1.) hexane, THF, 15 min, 2.) -78 deg C, 3 h 2: 91 percent / CH3CO2H / 6 h / Heating View Scheme

montmorillonite K-10 in benzene 24 h; Reflux;

<b>Multi-step reaction with 2 steps<br /> </b>1: 64 percent / p-toluenesulfonic acid, 4-A sieves / CH₂Cl₂ / 48 h / Heating<br />2: 1.) tert-butyllithium / 1.) ether, hexane, -20 deg C, 1 h, 2.) 1 h<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />0.25&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 &deg;C / |Inert atmosphere<br />2.1: n-butyllithium / hexane; diethyl ether / 3 h / 0 - 20 &deg;C / |Inert atmosphere<br />2.2: 0.17 h / 0 &deg;C / |Inert atmosphere<br />2.3: |Inert atmosphere<br /> <br /> &nbsp;