2,4,5-三氟苯甲酰乙酸乙酯合成路线 （共 34 条）
反应条件
1: dimethylformamide / 17 h / Heating 2: aq. H2SO4 / 2 h / Heating 3: (COCl)2, DMF / CH2Cl2 4: tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991
反应条件
1: aq. H2SO4 / 2 h / Heating 2: (COCl)2, DMF / CH2Cl2 3: tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991
反应条件
1: 1.) aluminum chloride / 1.) 50 deg C, 1 h, 2.) 80 deg C, 22 h 2: 94 percent / sodium hydroxide, sodium hypochlorite / H2O / 22 h / below 25 deg C 3: thionyl chloride / 4 h / 80 °C 4: 1.) biquinoline, n-butyllithium / 1.) THF, -30 deg C to - 5 deg C, 2.) -50 deg C, 0.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 168 - 174
反应条件
1: 94 percent / sodium hydroxide, sodium hypochlorite / H2O / 22 h / below 25 deg C 2: thionyl chloride / 4 h / 80 °C 3: 1.) biquinoline, n-butyllithium / 1.) THF, -30 deg C to - 5 deg C, 2.) -50 deg C, 0.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 1 p. 168 - 174
反应条件
toluene-4-sulfonic acid in water 5 h; Heating; Yield given;
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
反应条件
1: 1.) Mg/ethanol, CCl4 / 1.) ethanol, toluene, 1 h, 60-70 deg C; 2.) toluene, 0 to -5 deg C; 12 h, room temperature 2: p-toluenesulfonic acid / H2O / 5 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 29 - 37
参考文献
Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991
反应条件
oxalyl dichloride; C3H7MgCl 1.) CH2Cl2, DMF, 2.) THF; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 15 p. 2974 - 2977
反应条件
1: 1.) Ac2O / 2.) Et2O 2: NaH / tetrahydrofuran 3: 6 M HCl 4: 46 percent / acetonitrile View Scheme
参考文献
Renau, Thomas E.; Sanchez, Joseph P.; Shapiro, Martin A.; Dever, Julie A.; Gracheck, Stephen J.; Domagala, John M.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 15 p. 2974 - 2977
反应条件
Yield given. Multistep reaction;
参考文献
MacDonald, Alasdair A.; DeWitt, Sheila H.; Hogan, Eleonora M.; Ramage, Robert
Tetrahedron Letters, 1996 , vol. 37, # 27 p. 4815 - 4818
