1-环丙基-6,7-二氟-4-氧代-1,4-二氢喹啉-3-羧酸乙酯合成路线 （共 15 条）
反应条件
1: 95 percent / 10percent aq. HCl / ethanol / 3 h / 120 °C 2: 78 percent / pyridine / 1 h / 105 - 113 °C View Scheme
参考文献
Egawa; Kataoka; Shibamori; et al.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 181 - 185
反应条件
sulfuric acid in water; acetic acid 1.5 h; Heating;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: aq. HCl / Heating 2: 89 percent / pyridine / 18 h / Heating View Scheme
参考文献
Sanchez, Joseph P.; Domagala, John M.; Hagen, Susan E.; Heifetz, Carl L.; Hutt, Marland P.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, p. 983 - 991
参考文献
Taghavi-Moghadam, Shahriyar; Kleemann, Axel; Golbig, Klaus Georg
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 652 - 658
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=140 - 150°C; 2 h;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: in diethyl ether; ethanol
T=20°C; 2 h; Inert atmosphere;
2: With potassium carbonate in diethyl ether; ethanol; N,N-dimethyl-formamide
T=100°C; 2 h; Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
Location in patent: Page/Page column 200; 201 ;
反应条件
potassium fluoride in dimethyl sulfoxide
T=165°C; 1 h;
参考文献
Egawa; Kataoka; Shibamori; et al.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 181 - 185
反应条件
1: 1.) Mg/ethanol, CCl4 / 1.) ethanol, toluene, 1 h, 60-70 deg C; 2.) toluene, 0 to -5 deg C; 12 h, room temperature
2: p-toluenesulfonic acid / H2O / 5 h / Heating
3: acetic anhydride / 2 h / Heating
4: 94 percent / ethanol / 1 h / Ambient temperature
5: 84 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: triethylamine / chloroform
2: 1-methyl-pyrrolidin-2-one; potassium tert-butylate / tert-butyl alcohol
View Scheme
参考文献
Taghavi-Moghadam, Shahriyar; Kleemann, Axel; Golbig, Klaus Georg
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 652 - 658
反应条件
1: acetic anhydride / 2 h / Heating
2: 94 percent / ethanol / 1 h / Ambient temperature
3: 84 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
