1-环丙基-6,7-二氟-4-氧代-1,4-二氢喹啉-3-羧酸乙酯合成路线 （共 15 条）
反应条件
1: 94 percent / ethanol / 1 h / Ambient temperature
2: 84 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: p-toluenesulfonic acid / H2O / 5 h / Heating
2: acetic anhydride / 2 h / Heating
3: 94 percent / ethanol / 1 h / Ambient temperature
4: 84 percent / potassium carbonate / dimethylformamide / 2 h / 140 - 150 °C
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 29 - 37
反应条件
1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 24 h
2: triethylamine / toluene / 5 h / 90 °C
3: diethyl ether; ethanol / 3 h / 25 °C
4: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C
View Scheme
参考文献
Gomez, Catherine; Ponien, Prishila; Serradji, Nawal; Lamouri, Aazdine; Pantel, Alix; Capton, Estelle; Jarlier, Vincent; Anquetin, Guillaume; Aubry, Alexandra
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 948 - 956
反应条件
1: diethyl ether; ethanol / 3 h / 25 °C
2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C
View Scheme
参考文献
Gomez, Catherine; Ponien, Prishila; Serradji, Nawal; Lamouri, Aazdine; Pantel, Alix; Capton, Estelle; Jarlier, Vincent; Anquetin, Guillaume; Aubry, Alexandra
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 948 - 956
反应条件
1.1: triethylamine / toluene / 3 h / 90 °C / |Inert atmosphere
2.1: ethanol; diethyl ether / 2 h / 20 °C / |Inert atmosphere
2.2: 2 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
