1: methylmagnesium bromide With N,N,N',N',N'',N''-hexamethylphosphoric triamide; copper(I) bromide dimethylsulfide complex in tetrahydrofuran T=-40°C; 0.5 h; Inert atmosphere; 2: chloro-trimethyl-silane; 2-methylcyclohex-2-en-1-one in tetrahydrofuran T=-40°C; 1 h; Inert atmosphere; 3: With triethylamine in tetrahydrofuran Inert atmosphere;

1,1,1,3,3,3-hexamethyl-disilazane; sodium iodide in acetonitrile

1: 95 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 2.5 h / Ambient temperature 2: 1) LDA / 1) THF, hexane, -70 deg C, 1.5 h, 2) up to r.t. View Scheme

1,1,1,3,3,3-hexamethyl-disilazane in dichloromethane 1) 0 deg C, 10 min, 2) 20 deg C, 1 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

lithium diisopropyl amide 1) THF, hexane, -70 deg C, 1.5 h, 2) up to r.t.; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

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