4-（4-溴苯基）丁酸甲酯合成路线 （共 7 条）
反应条件
toluene-4-sulfonic acid in benzene
Heating;
参考文献
Christiansen, Elisabeth; Due-Hansen, Maria E.; Urban, Christian; Grundmann, Manuel; Schmidt, Johannes; Hansen, Steffen V. F.; Hudson, Brian D.; Zaibi, Mohamed; Markussen, Stine B.; Hagesaether, Ellen; Milligan, Graeme; Cawthorne, Michael A.; Kostenis, Evi; Kassack, Matthias U.; Ulven, Trond
Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 982 - 992
反应条件
1.1: 53 percent / sodium hydrogensulfate; p-hydroquinone; 4-tert-butylcatechol / diethyl ether / 3 h / 200 °C
2.1: BMS / bis-(2-methoxy-ethyl) ether / 0 - 140 °C
2.2: aq. NaOH; H2O2 / 25 - 50 °C
3.1: CrO3; aq. H2SO4 / acetone / 20 °C
4.1: 83 percent / thionyl chloride / Heating
View Scheme
参考文献
Zaidlewicz, Marek; Wolan, Andrzej
Journal of Organometallic Chemistry, 2002 , vol. 657, # 1-2 p. 129 - 135
反应条件
1.1: 90 percent / diethyl ether / 20 °C
2.1: 53 percent / sodium hydrogensulfate; p-hydroquinone; 4-tert-butylcatechol / diethyl ether / 3 h / 200 °C
3.1: BMS / bis-(2-methoxy-ethyl) ether / 0 - 140 °C
3.2: aq. NaOH; H2O2 / 25 - 50 °C
4.1: CrO3; aq. H2SO4 / acetone / 20 °C
5.1: 83 percent / thionyl chloride / Heating
View Scheme
参考文献
Zaidlewicz, Marek; Wolan, Andrzej
Journal of Organometallic Chemistry, 2002 , vol. 657, # 1-2 p. 129 - 135
反应条件
1: CrO3; aq. H2SO4 / acetone / 20 °C
2: 83 percent / thionyl chloride / Heating
View Scheme
参考文献
Zaidlewicz, Marek; Wolan, Andrzej
Journal of Organometallic Chemistry, 2002 , vol. 657, # 1-2 p. 129 - 135
反应条件
1.1: BMS / bis-(2-methoxy-ethyl) ether / 0 - 140 °C
1.2: aq. NaOH; H2O2 / 25 - 50 °C
2.1: CrO3; aq. H2SO4 / acetone / 20 °C
3.1: 83 percent / thionyl chloride / Heating
View Scheme
参考文献
Zaidlewicz, Marek; Wolan, Andrzej
Journal of Organometallic Chemistry, 2002 , vol. 657, # 1-2 p. 129 - 135
反应条件
1: 44 percent / AlCl3 / 5 h / 90 °C
2: 70 percent / Zn-Hg, cc. HCl / 185 - 190 °C / 1.5 Torr
3: 100 percent / p-toulenesulphonic acid / benzene / Heating
View Scheme
参考文献
Mathur, Naresh C.; Snow, Miles S.; Young, Kent M.; Pincock, James A.
Tetrahedron, 1985 , vol. 41, # 8 p. 1509 - 1516
反应条件
1: 70 percent / Zn-Hg, cc. HCl / 185 - 190 °C / 1.5 Torr
2: 100 percent / p-toulenesulphonic acid / benzene / Heating
View Scheme
参考文献
Mathur, Naresh C.; Snow, Miles S.; Young, Kent M.; Pincock, James A.
Tetrahedron, 1985 , vol. 41, # 8 p. 1509 - 1516
