N-[4-(苄氧基)环己基]-5-氯戊烷酰胺合成路线 （共 5 条）
反应条件
tris-(2-chloro-ethyl)-amine; phosphorus trichoride 1) benzene, 30 deg C, 1 h; 2) benzene, overnight; Yield given. Multistep reaction;
参考文献
Nishi; Tabusa; Tanaka; Shimizu; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1140 - 1147
反应条件
potassium carbonate in tetrahydrofuran; water
0.5 h; Ambient temperature;
参考文献
Nishi; Tabusa; Tanaka; Shimizu; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1140 - 1147
反应条件
1: 74 percent / 60percent NaH, DMSO / 1 h / Ambient temperature
2: 83 percent / 85percent KOH / H2O; 2-methoxy-ethanol / 20 h / Heating
3: 80 percent / K2CO3 / tetrahydrofuran; H2O / 0.5 h / Ambient temperature
View Scheme
参考文献
Nishi; Tabusa; Tanaka; Shimizu; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1140 - 1147
反应条件
1: 74 percent / 60percent NaH, DMSO / 1 h / Ambient temperature
2: 83 percent / 85percent KOH / H2O; 2-methoxy-ethanol / 20 h / Heating
3: 80 percent / K2CO3 / tetrahydrofuran; H2O / 0.5 h / Ambient temperature
View Scheme
参考文献
Nishi; Tabusa; Tanaka; Shimizu; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1140 - 1147
反应条件
1: 83 percent / 85percent KOH / H2O; 2-methoxy-ethanol / 20 h / Heating
2: 80 percent / K2CO3 / tetrahydrofuran; H2O / 0.5 h / Ambient temperature
View Scheme
参考文献
Nishi; Tabusa; Tanaka; Shimizu; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 3 p. 1140 - 1147
