2-溴甲基-3-硝基苯甲酸甲酯合成路线 （共 18 条）
反应条件
potassium carbonate in N,N-dimethyl acetamide T=20 - 50°C; 40.5 h; Inert atmosphere;
参考文献
Greig, Nigel H.; Luo, Weiming; Tweedie, David; Holloway, Harold W.; Yu, Qian-Sheng; Goetzl, Edward J.
Patent: US2013/143922 A1, 2013 ;
Location in patent: Paragraph 0085; 0086 ;
反应条件
1: 3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine With palladium 10 on activated carbon; hydrogen in methanol T=25 - 35°C; 2 h; 2: 2-(bromomethyl)-3-nitrobenzoic acid,methyl ester With triethylamine in N,N-dimethyl-formamide T=25 - 35°C; 6 h;
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi
Patent: WO2013/5229 A1, 2013 ;
Location in patent: Page/Page column 8 ;
反应条件
in 1,4-dioxane; water
参考文献
E. I. Du Pont de Nemours and Company
Patent: US4521241 A1, 1985 ;
反应条件
1: Et3N / dimethylformamide / 80 °C 2: H2 / 10 percent Pd/C / methanol View Scheme
参考文献
RATIOPHARM GMBH; STIEGEL, Hans-Huenter^, Dr.; ALBRECHT, Wolfgang, Dr.; BRUECK, Sandra; PAETZ, Jana; MEERGANS, Dominique
Patent: WO2011/50962 A1, 2011 ;
反应条件
1: 81 percent / ammonia / methanol / 2 h / 20 °C
2: 83 percent / ammonium formate / Pd/C / dimethylformamide / 0.5 h / 100 °C
3: aq. NaHCO3 / ethyl acetate / 0.5 h / 20 °C
4: NaOH / methanol / 20 °C
View Scheme
参考文献
Jagtap, Prakash G.; Southan, Garry J.; Baloglu, Erkan; Ram, Siya; Mabley, Jon G.; Marton, Anita; Salzman, Andrew; Szabo, Csaba
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 81 - 85
反应条件
in DMF (N,N-dimethyl-formamide)
T=130°C; 12 h;
参考文献
Rehwinkel, Hartmut; Baeurle, Stefan; Berger, Markus; Schmees, Norbert; Schaecke, Heike; Krolikiewicz, Konrad; Mengel, Anne; Nguyen, Duy; Jaroch, Stefan; Skuballa, Werner
Patent: US2005/222154 A1, 2005 ;
Location in patent: Page/Page column 15 ;
US 20050222154 A1
反应条件
1: pyridine / ethanol / 48 h / Heating
2: H2 / Pd/C / ethyl acetate / 3 h
View Scheme
参考文献
Suizu, Mamiko; Muroya, Yohei; Kakuta, Hiroki; Kagechika, Hiroyuki; Tanatani, Aya; Nagasawa, Kazuo; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1098 - 1102
反应条件
sodium azide in DMF (N,N-dimethyl-formamide); water
参考文献
SCHERING AKTIENGESELLSCHAFT
Patent: WO2005/34939 A1, 2005 ;
Location in patent: Page/Page column 53 ;
