反应条件
1: 94 percent / p-TsOH / benzene / 1 h / Heating
2: imidazole / dimethylformamide / 6 h / Ambient temperature
3: 1.) 50 percent NaH, ethyl oxalate; 2.) K2CO3 / 1.) oil, THF, EtOH, 4 h, r.t.; 2.) oil, THF, H2O, 1.5 h, 0 deg C
4: 79.8 percent / acetic acid; tetrahydrofuran; H2O / 72 h / Ambient temperature
View Scheme
参考文献
Machiya; Ichimoto; Tonari; et al.
Agricultural and Biological Chemistry, 1985 , vol. 49, # 6 p. 1767 - 1773
