1-苯基-5-三氟甲基-1H-吡唑-4-羧酸合成路线 （共 9 条）
反应条件
1: With potassium hydroxide in ethanol T=20°C; 3.25 h; Heating / reflux; 2: With hydrogenchloride in water pH=1;
参考文献
L'OREAL
Patent: US2006/34786 A1, 2006 ;
Location in patent: Page/Page column 60 ;
US 20060034786 A1
反应条件
1: 1-phenyl-5-trifluoromethyl-1H-pyrazole With n-butyllithium; N,N,N',N'',N''-pentamethyldiethylenetriamine; diisopropylamine in tetrahydrofuran; hexane T=-75°C; 0.0833333 h; 2: carbon dioxide Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
potassium hydroxide in ethanol 4 h; Ambient temperature;
参考文献
Okada, Etsuji; Masuda, Ryoichi; Hojo, Masaru
Heterocycles, 1992 , vol. 34, # 4 p. 791 - 798
反应条件
1.1: ethanol / 2 h / Heating 1.2: 78 percent / cc. HCl / CH2Cl2 / 1 h / 25 °C 2.1: 62 percent / diisopropylamine; N,N,N',N",N"-pentamethyldiethylenetriamine; butyllithium / tetrahydrofuran; hexane / 0.08 h / -75 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 17 p. 2913 - 2920
反应条件
1: 95 percent / acetonitrile / 1 h / Ambient temperature 2: 85 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 34, # 4 p. 791 - 798
反应条件
1: 80 percent / acetonitrile / 1 h / Ambient temperature 2: 85 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 34, # 4 p. 791 - 798
反应条件
1: 78 percent / triethylamine / ethanol / -15 deg C - RT, 1 h 2: 67 percent / KOH / ethanol / 2 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, p. 739 - 740
反应条件
1: 78 percent / triethylamine / ethanol / -15 deg C - RT, 1 h 2: 67 percent / KOH / ethanol / 2 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, p. 739 - 740
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane 0.5 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; GILMORE, John L.; SHEPPECK, James E.
Patent: WO2011/17578 A1, 2011 ;
Location in patent: Page/Page column 163 ;
