(S)-α-Boc-氨基-β-丙内酯合成路线 (共 19 条)
反应条件
toluene-4-sulfonic acid; trifluoroacetic acid T=0 - 5°C; 10 h;
参考文献
Journal of the American Chemical Society, , vol. 110, p. 2237
反应条件
trifluoroacetic acid T=0 - 5°C; 0.25 h;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 22 p. 4430 - 4438
反应条件
1: 79 percent / silver oxide, molecular sieves 4 Angstroem / diethyl ether / Ambient temperature 2: NaH / dimethylformamide / 3 h / Ambient temperature 3: diethyl ether 4: 1) 2,2'-azoisobutyronitrile; 2) triphenyltin hydride / 1) benzene, reflux, 1 h; 2) benzene, reflux, 1 h View Scheme
参考文献
Soucy, Francois; Wernic, Dominik; Beaulieu, Pierre
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 11 p. 2885 - 2887
反应条件
in acetonitrile T=50°C;
参考文献
Bruton, Gordon; Faller, Andrew; Orlek, Barry Sidney; Rana, Kishore Kalidas; Walker, Graham
Patent: US2003/199571 A1, 2003 ;
Location in patent: Page/Page column 21 ;
反应条件
sodium hydride 1.) THF, RT, 10 min, 2.) THF, RT, 2 h; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 96 - 108
反应条件
in tetrahydrofuran; acetonitrile T=50°C; Inert atmosphere;
参考文献
Marsault, Eric; Fraser, Graeme L.; Benakli, Kamel; St-Louis, Carl; Rouillard, Alain; Thomas, Helmut
Patent: US2010/93720 A1, 2010 ;
Location in patent: Page/Page column 38 ;
US 20100093720 A1
反应条件
in tetrahydrofuran; acetonitrile T=50°C;
参考文献
Marsault, Eric; Benakli, Kamel; Beaubien, Sylvie; Saint-Louis, Carl; Deziel, Robert; Fraser, Graeme
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4187 - 4190
反应条件
in acetonitrile T=20°C; 28.08 h; Inert atmosphere;
参考文献
Marsault, Eric; Fraser, Graeme L.; Benakli, Kamel; St-Louis, Carl; Rouillard, Alain; Thomas, Helmut
Patent: US2010/93720 A1, 2010 ;
Location in patent: Page/Page column 37 ;
US 20100093720 A1
反应条件
in acetonitrile T=20°C;
参考文献
Marsault, Eric; Benakli, Kamel; Beaubien, Sylvie; Saint-Louis, Carl; Deziel, Robert; Fraser, Graeme
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4187 - 4190