N-甲基-1H-吲哚-5-乙基磺酰胺合成路线 （共 12 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol; ethyl acetate T=70 - 80°C; 6 h; Product distribution / selectivity;
参考文献
USV LIMITED
Patent: WO2009/118753 A2, 2009 ;
Location in patent: Page/Page column 31 ;
反应条件
quinoline; copper(I) oxide T=180 - 200°C; 6 h;
参考文献
USV LIMITED
Patent: WO2009/118753 A2, 2009 ;
Location in patent: Page/Page column 26 ;
反应条件
1: With potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=25 - 85°C; Inert atmosphere; 2: With water in 1-methyl-pyrrolidin-2-one T=25°C; 0.5 h;
参考文献
WO2011/21000 A2, ;
Page/Page column 37 ;
反应条件
1: With potassium tert-butylate in 1-methyl-pyrrolidin-2-one T=80 - 85°C; 2: With water in 1-methyl-pyrrolidin-2-one T=25°C; 0.5 h;
参考文献
WO2011/21000 A2, ;
Page/Page column 35; 36 ;
反应条件
Raney nickel in isopropyl alcohol T=70 - 75°C; 3 h; Product distribution / selectivity;
参考文献
IND-SWIFT LABORATORIES LIMITED; CHIDAMBARAM, Venkateswaran, Srinivasan; AGGARWAL, Ashvin, Kumar; WADHWA, Lalit
Patent: WO2010/4580 A2, 2010 ;
Location in patent: Page/Page column 18-19 ;
反应条件
pyridine T=100°C; 3 h; Autoclave;
参考文献
USV LIMITED
Patent: WO2009/118753 A2, 2009 ;
Location in patent: Page/Page column 32 ;
反应条件
1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C 2.1: dichloromethane / 1.5 h / 25 °C 3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 3.2: 25 °C 4.1: potassium hydroxide; ethanol / 15 - 25 °C 5.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 5.2: 0.5 h / 25 °C View Scheme
反应条件
1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 1.2: 25 °C 2.1: potassium hydroxide; ethanol / 15 - 25 °C 3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 3.2: 0.5 h / 25 °C View Scheme
反应条件
1.1: dichloromethane / 1.5 h / 25 °C 2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 2.2: 25 °C 3.1: potassium hydroxide; ethanol / 15 - 25 °C 4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 4.2: 0.5 h / 25 °C View Scheme
反应条件
1.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 1.2: 10 - 15 °C / pH 8 2.1: hydrogen; acetic acid / palladium 10 on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 2.2: 10 °C / pH 7.5 - 8.5 View Scheme
参考文献
CIPLA LIMITED; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra Narayanrao; CHIKHALIKAR, Sandip Vasant; GHAGARE, Maruti; CURTIS, Philip Anthony
Patent: WO2011/21000 A2, 2011 ;
