1: 34 percent / anhydrous sodium acetate, Br2 / acetic acid / 1.) 80 deg C, 6 h, 2.) 23 deg C, 64 h; 2: 34 percent / NaHCO3 / palladium acetate / dimethylformamide / 6 h / 120 °C 3: NaBH4 / ethanol; tetrahydrofuran 4: aq. 48percent HBr / acetic acid View Scheme