3-羟基丙基甲基氨基甲酸叔丁酯合成路线 （共 13 条）
反应条件
1: With 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 1 h; 2: With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 2 h;
参考文献
EP2409977 A1, ;
Page/Page column 62 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 0.5 h;
参考文献
Journal of Organic Chemistry, , vol. 53, # 10 p. 2226 - 2232
反应条件
1-methylimidazolium tetrafluoroborate T=30 - 35°C; 0.0833333 h;
参考文献
Tetrahedron Letters, , vol. 49, # 16 p. 2527 - 2532
反应条件
diisobutylaluminium hydride in diethyl ether T=-78 - 20°C;
参考文献
Tetrahedron Letters, , vol. 46, # 42 p. 7147 - 7149
反应条件
sodium carbonate in tetrahydrofuran; water T=0 - 20°C; Product distribution / selectivity;
参考文献
US2009/215828 A1, ;
Page/Page column 17 ;
US 20090215828 A1
反应条件
1: 93 percent / NaH 2: 79 percent / DIBAL-H View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 50, # 5-6 p. 323 - 326
反应条件
1: 86 percent / imidazole / dimethylformamide 2: 1.) sodium hydride / 1.) 30 min, THF, 2.) overnight 3: 96.8 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 10 p. 2226 - 2232
反应条件
1: 1.) sodium hydride / 1.) 30 min, THF, 2.) overnight 2: 96.8 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 10 p. 2226 - 2232
反应条件
1: NEt3 2: 93 percent / NaH / tetrahydrofuran 3: 79 percent / DIBAL-H / diethyl ether / -78 - 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 42 p. 7147 - 7149
反应条件
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide 1.) THF, RT, 22 h, 2.) THF, 50 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Synthetic Communications, , vol. 25, # 14 p. 2135 - 2143
