1: 3-Iodo-4-methoxy-2(1H)-quinolinone With isopropylmagnesium chloride in tetrahydrofuran T=-30°C; 0.166667 h; 2: (+/-)-3,3-dimethyloxirane-2-carboxaldehyde in tetrahydrofuran T=-30°C; 0.5 h; Further stages.;

1: 3-Iodo-4-methoxy-2(1H)-quinolinone With isopropylmagnesium chloride in tetrahydrofuran T=-30°C; 0.166667 h; 2: (R)-3,3-dimethyloxirane-2-carboxaldehyde in tetrahydrofuran T=-30°C; 0.5 h; Further stages.;

1: Et3N, <Pd(PPh3)2>Cl2/CuI / Heating 2: 11 percent / LiAlH4 / tetrahydrofuran / 4 h / Ambient temperature View Scheme