(1S)-1-(2R)-环氧乙基-2-苯乙基氨基甲酸叔丁酯合成路线 （共 74 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Organic letters, , vol. 3, # 15 p. 2349 - 2351
反应条件
1.1: CuBr*SMe2 / tetrahydrofuran 2.1: p-TsOH*H2O 2.2: KOH / methanol View Scheme
参考文献
Organic letters, , vol. 3, # 15 p. 2349 - 2351
反应条件
1.1: NaH / tetrahydrofuran 2.1: CuBr*SMe2 / tetrahydrofuran 3.1: p-TsOH*H2O 3.2: KOH / methanol View Scheme
参考文献
Organic letters, , vol. 3, # 15 p. 2349 - 2351
反应条件
1.1: water; sodium tetrahydroborate / ethanol / 1 h / -8 - 5 °C / Inert atmosphere 2.1: sodium methylate / methanol / 2 h / 20 - 30 °C / Inert atmosphere 3.1: triethylamine; p-toluenesulfonyl chloride / di(n-butyl)tin oxide / 1-methyl-pyrrolidin-2-one / 1 h / 20 - 30 °C / Inert atmosphere 3.2: 1 h / 20 - 30 °C / Inert atmosphere View Scheme
反应条件
1.1: hydrogenchloride; dimethyl sulfoxide / water / 4 h / 20 - 30 °C / Inert atmosphere 1.2: 0 - 10 °C 1.3: 3 h / 0 - 30 °C / Inert atmosphere 2.1: water; sodium tetrahydroborate / ethanol / 1 h / -8 - 5 °C / Inert atmosphere 3.1: sodium methylate / methanol / 2 h / 20 - 30 °C / Inert atmosphere 4.1: triethylamine; p-toluenesulfonyl chloride / di(n-butyl)tin oxide / 1-methyl-pyrrolidin-2-one / 1 h / 20 - 30 °C / Inert atmosphere 4.2: 1 h / 20 - 30 °C / Inert atmosphere View Scheme
反应条件
1.1: t-BuOK / tetrahydrofuran / 2 h / Heating 1.2: tetrahydrofuran / 4 h / 0 °C 2.1: 81 percent / LiCl; MeSO3H / tetrahydrofuran / 2 h / 70 °C 3.1: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C 4.1: 96 percent / t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 16 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 5 p. 1629 - 1633
反应条件
1: 81 percent / LiCl; MeSO3H / tetrahydrofuran / 2 h / 70 °C 2: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C 3: 96 percent / t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 16 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 5 p. 1629 - 1633
反应条件
1: aq. HCl / tetrahydrofuran / 48 h / 5 °C 2: 97 percent / H2, Pd(OH)2/C / methanol 3: 1) Et3N, 2) KOH / 1) THF, 0-5 deg C, 30 min; room temperature, 3.5 h, 2) THF, MeOH, 0-5 deg C 15 min; room temperature, 75 min View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 11 p. 3635 - 3645
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran 14 h;
参考文献
Journal of Organic Chemistry, , vol. 74, # 16 p. 5975 - 5982
反应条件
in tetrahydrofuran T=-5°C; 0.5 h; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 50, # 23 p. 4615 - 4625
