(1S)-1-(2R)-环氧乙基-2-苯乙基氨基甲酸叔丁酯合成路线 （共 74 条）
反应条件
1: pyridine 3: cesium carbonate / methanol; tetrahydrofuran View Scheme
参考文献
Heterocycles, , vol. 54, # 1 p. 77 - 80
反应条件
2: cesium carbonate / methanol; tetrahydrofuran View Scheme
参考文献
Heterocycles, , vol. 54, # 1 p. 77 - 80
反应条件
1.1: sodium tetrahydroborate; iodine / tetrahydrofuran / Cooling with ice; Reflux 2.1: potassium carbonate / methanol; water / 0.17 h / Reflux 2.2: 1 h / Heating 3.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1.08 h / 15 °C / Cooling with ice 4.1: lithium / tetrahydrofuran / 3 h / -65 °C / Inert atmosphere 5.1: palladium hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr 6.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice 7.1: potassium hydroxide / tetrahydrofuran; methanol / Cooling with ice View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 53, # 3 p. 148 - 152
反应条件
1.1: potassium carbonate / methanol; water / 0.17 h / Reflux 1.2: 1 h / Heating 2.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 1.08 h / 15 °C / Cooling with ice 3.1: lithium / tetrahydrofuran / 3 h / -65 °C / Inert atmosphere 4.1: palladium hydroxide on carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr 5.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice 6.1: potassium hydroxide / tetrahydrofuran; methanol / Cooling with ice View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 53, # 3 p. 148 - 152
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran 2: N-bromosuccinmide / tetrahydrofuran / -40 °C 3: sodium tetrahydroborate / ethanol / -78 °C 4: potassium hydroxide / ethanol View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 52 p. 14772 - 14784
反应条件
1: tetrahydrofuran 2: lithium hexamethyldisilazane / tetrahydrofuran 3: N-bromosuccinmide / tetrahydrofuran / -40 °C 4: sodium tetrahydroborate / ethanol / -78 °C 5: potassium hydroxide / ethanol View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 52 p. 14772 - 14784
反应条件
1: copper(I) bromide dimethylsulfide complex / tetrahydrofuran; toluene / 1 h / -10 °C / Inert atmosphere 2: toluene-4-sulfonic acid / methanol; water / 6 h / 50 °C 3: 2-picoline / ethyl acetate / 12 h / 0 - 5 °C 4: triethylamine / ethyl acetate / 2 h 5: potassium hydroxide / methanol; dichloromethane / 2 h / 0 - 20 °C View Scheme
参考文献
Bulletin of the Korean Chemical Society, , vol. 33, # 7 p. 2213 - 2218
反应条件
1: toluene-4-sulfonic acid / methanol; water / 6 h / 50 °C 2: 2-picoline / ethyl acetate / 12 h / 0 - 5 °C 3: triethylamine / ethyl acetate / 2 h 4: potassium hydroxide / methanol; dichloromethane / 2 h / 0 - 20 °C View Scheme
参考文献
Bulletin of the Korean Chemical Society, , vol. 33, # 7 p. 2213 - 2218
反应条件
1: 2-picoline / ethyl acetate / 12 h / 0 - 5 °C 2: triethylamine / ethyl acetate / 2 h 3: potassium hydroxide / methanol; dichloromethane / 2 h / 0 - 20 °C View Scheme
参考文献
Bulletin of the Korean Chemical Society, , vol. 33, # 7 p. 2213 - 2218
反应条件
1: N-Acetyl-Dl-leucine / toluene; propan-1-ol / 20 - 95 °C / |Resolution of racemate 2: triethylamine / dichloromethane / 29 h 3: sodium hydrogencarbonate; Oxonereg; / water; acetone; ethyl acetate / 17 h 4: hexane / 1 h / 5 - 45 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 15, # 2 p. 331 - 338
