1: 2N NaOH / dioxane / 4 h / Ambient temperature 2: 32percent NH4OH / methanol / 6 h / sealed flask 3: 98 percent / Et3N / CH2Cl2 / 0.5 h / -10 - -5 °C 4: 86 percent / t-BuOK / 2-methyl-propan-2-ol / 3 h / Ambient temperature 5: RED-AL / toluene / 4 h / Ambient temperature View Scheme

1: 2N NaOH / dioxane / 4 h / Ambient temperature 2: 32percent NH4OH / methanol / 6 h / sealed flask 3: ethyl acetate / 16 h View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=0 - 5&deg;C;&nbsp;0.5&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 61 percent / pyridine / 2 h / -10 &deg;C<br />2: 84 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 5 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: MCPBA / CH₂Cl₂ / 0 deg C, 1.5 h, then RT, 24 h<br />2: 1.) NaOH / 1.) H₂O, 70 deg C; 2.) H₂O, 70 deg C, 2.5 h<br />3: 61 percent / pyridine / 2 h / -10 &deg;C<br />4: 84 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 5 &deg;C<br /> <br /> &nbsp;