5’-(4,4’-二甲氧基三苯基)-3’-脱氧胸苷 2’-(2-氰乙基-N,N-二异丙基)亚磷酰胺合成路线 （共 12 条）
反应条件
chloro-trimethyl-silane in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Dabkowski, Wojciech; Tworowska, Izabela; Michalski, Jan; Cramer, Friedrich
Chemical Communications, 1997 , # 9 p. 877 - 878
反应条件
in tetrahydrofuran according to ref 3) with modifications;
参考文献
Tetrahedron Letters, , vol. 24, # 52 p. 5843 - 5846
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 0.166667 h; Ambient temperature;
参考文献
Zhang, Zhaoda; Tang, Jin Yan
Tetrahedron Letters, 1996 , vol. 37, # 3 p. 331 - 334
反应条件
1: 67 percent / PCl3 / diethyl ether / 1.) -10 grad C, 2.5 h, 2.) room temperature, 1 h 2: 1.) isopropylethylamine / 1.) CH2Cl2, -10 grad C, 30 min, 2.) CH2Cl2, 30 min View Scheme
参考文献
Tetrahedron Letters, , vol. 27, # 2 p. 199 - 202
反应条件
1: DMAP / pyridine / 1.5 h / 20 °C 2: EtN(iso-Pr)2 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 60, # 41 p. 9273 - 9281
反应条件
1: DMAP / pyridine / 1.5 h / 20 °C 2: EtN(iso-Pr)2 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 60, # 41 p. 9273 - 9281
反应条件
1: 95 percent / Et3N / tetrahydrofuran / Ambient temperature 2: 94 percent / N,N-diisopropylethylamine / acetonitrile / 0.17 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 3 p. 331 - 334
反应条件
1: diethyl ether / 20 h / Ambient temperature 2: tetrahydrofuran / according to ref 3) with modifications View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 52 p. 5843 - 5846
反应条件
N-ethyl-N-isopropylamine 1.) CH2Cl2, -10 grad C, 30 min, 2.) CH2Cl2, 30 min; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 27, # 2 p. 199 - 202
反应条件
1H-tetrazole; triethylamine 1.) dioxane, 20 min; 2.) acetonitril, 30 min; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 27, # 20 p. 2271 - 2274
