DMT-dA(bz)亚磷酸酰胺合成路线 （共 9 条）
反应条件
saccharin-N-methylimidazole salt T=20°C; 5 - 7 h;
参考文献
AVECIA BIOTECHNOLOGY INC.; AVECIA LIMITED
Patent: WO2004/35599 A1, 2004 ;
Location in patent: Page 9-10 ;
反应条件
chloro-trimethyl-silane in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Dabkowski, Wojciech; Tworowska, Izabela; Michalski, Jan; Cramer, Friedrich
Chemical Communications, 1997 , # 9 p. 877 - 878
反应条件
1: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine With N-ethyl-N,N-diisopropylamine in dichloromethane 0.166667 h; 2: (N,N-diisopropylamino)-(2-cyanoethoxy)chlorophosphine With [C6mim][FAP] 1.75 h;
参考文献
Amigues, Eric J.; Hardacre, Christopher; Keane, Gillian; Migaud, Marie E.; Norman, Sarah E.; Pitner, William R.
Green Chemistry, 2009 , vol. 11, # 9 p. 1391 - 1396
反应条件
pyridine in acetonitrile T=20°C; 12 h;
参考文献
US6335439 B1, ;
Example 14 ;
反应条件
1: 95 percent / Et3N / tetrahydrofuran / Ambient temperature 2: N,N-diisopropylethylamine / tetrahydrofuran; acetonitrile / 0.17 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 3 p. 331 - 334
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; acetonitrile 0.166667 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 37, # 3 p. 331 - 334
反应条件
1: diethyl ether / 20 h / Ambient temperature 2: tetrahydrofuran / according to ref 3) with modifications View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 52 p. 5843 - 5846
反应条件
1: diethyl ether / 20 h / Ambient temperature 2: tetrahydrofuran / according to ref 3) with modifications View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 52 p. 5843 - 5846
反应条件
1: tetrazole / acetonitrile 2: pyridine / 8 h View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 51 p. 8971 - 8974
