1: 42 percent / NH3(liq.), t-C4H9OK, air / Irradiation 2: 96 percent / 30percent Pd/C / 4 h / 250 °C 3: 90 percent / 48percent HBr / acetic acid / 3 h / 100 °C View Scheme

<b>Multi-step reaction with 5 steps<br /> </b>1: 95 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 20 h / Ambient temperature<br />2: 95 percent / H₂ / Pd/C<br />3: 93 percent / polyphosphoric acid / 4 h / 40 &deg;C<br />4: 3 percent / HBr<br />5: 100 percent / K₂CO₃ / dimethylformamide / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 67 percent / polyphosphoric acid / CHCl₃ / 40 &deg;C<br />2: 100 percent / K₂CO₃ / dimethylformamide / Heating<br /> <br /> &nbsp;