2-甲基-2-丙基{(1R)-1-[(2R)-2-环氧乙烷基]-2-苯基乙基}氨基甲酸酯合成路线 （共 2 条）
反应条件
Multi-step reaction with 5 steps 1.1: dichloromethane / 3 h / Reflux2.1: triethylamine / dichloromethane / Reflux3.1: hydrogen; triethanolamine / palladium 10 on activated carbon / methanol / 2 h / 40 - 45 °C4.1: hydrogenchloride; water / 2 h / Reflux5.1: 1-methyl-pyrrolidin-2-one / 10 h / -4 - 30 °C5.2: 1 h / 45 - 50 °C
参考文献
Vellanki, Siva Rama Prasad; Sahu, Arabinda; Katukuri, Aravind Kumar; Vanama, Vikram; Kothari, Satishbabu; Ponnekanti, Venkata Suryanarayana; Datta, Debashish Patent: US2012/251826 A1, 2012 ;
反应条件
Multi-step reaction with 3 steps 1: ethanol / 3 h / 80 °C2: aq. Na2CO3 / CH2Cl2 / 0 - 20 °C3: TFA / CH2Cl2 / 1 h
参考文献
Ali, Akbar; Reddy, G. S. Kiran Kumar; Cao, Hong; Anjum, Saima Ghafoor; Nalam, Madhavi N. L.; Schiffer, Celia A.; Rana, Tariq M. Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7342 - 7356
