1: in toluene T=50°C; P=600.06 Torr; 0.333333 h; microwave irradiation; 2: With ammonium chloride in toluene 3: With water Further stages. Title compound not separated from byproducts.;

1: (1S,3R,4R)-2-benzyl-3-(2-hydroxy-2-propyl)-2-azabicyclo<2.2.1>heptane / toluene; hexane / 0 - 20 °C 2: 1.) HCl, 2.) NaOH / 1.) methanol, room temperature View Scheme

1: potassium carbonate; sodium iodide; (S)-(+)-2-((benzyloxy)diphenylmethyl)tetrahydrothiophene / acetonitrile / 48 h / |Inert atmosphere; |Schlenk technique 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere 3: trifluoroacetic acid / water; acetone / 10 - 20 °C / |Inert atmosphere View Scheme

1: in toluene T=50°C; P=600.06 Torr; 0.333333 h; microwave irradiation; 2: With ammonium chloride in toluene 3: With water Further stages. Title compound not separated from byproducts.;

1: in toluene T=50°C; P=600.06 Torr; 0.333333 h; microwave irradiation; 2: With ammonium chloride in toluene 3: With water Further stages. Title compound not separated from byproducts.;

1.1: (S)-ALB; KO-t-Bu / tetrahydrofuran; CH2Cl2 / -40 °C 2.1: 100 percent / HF; pyridine / tetrahydrofuran / 0 - 20 °C 3.1: Dess-Martin periodinane / CH2Cl2 / 14 h / 20 °C 4.1: TMSCl; DBU / CH2Cl2 / 1 h / 0 °C 4.2: 83 percent / AcOH / 0.25 h / -78 °C 5.1: 85 percent / Zn dust; NH4Cl / aq. methanol / 20 °C 6.1: 81 percent / NaBH3CN; MS 3A / methanol / 3 h / 20 °C 7.1: 30 percent / LiAlH4 / tetrahydrofuran / 20 °C View Scheme

1: 93 percent / 3,4,5-trimethylthiazolium iodide; DBU; isopropanol / CHCl3 / 24 h / 60 °C 2: aq. HCl / tetrahydrofuran / 0 - 20 °C View Scheme

bis(acetylacetonate)nickel(II) in toluene; acetonitrile T=0°C; 1 h;