(1R,2S)-(-)-反-2-苯基-1-环己醇合成路线 （共 53 条）
反应条件
1: Amberlyst 15 / methanol / 6.5 h / 40 °C 2: 96 percent / triethylamine / CH2Cl2 / 1.5 h / 20 °C 3: 213 mg / toluene 4: 85 percent / LiALH4 / tetrahydrofuran View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 3595 - 3600
反应条件
1: trimethylsilyl bromide; triethylamine / acetonitrile / 18 h / -25 °C / |Inert atmosphere 2: silver nitrate / acetone; water / 3 h / |Reflux 3: acetic acid; zinc / 24 h 4: sodium cyanoborohydride / 1 h 5: hydrogen / methanol / 3.5 h / 20 °C / 18751.9 Torr / |Autoclave 6: dichloromethane / 2 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
1: silver nitrate / acetone; water / 3 h / |Reflux 2: acetic acid; zinc / 24 h 3: sodium cyanoborohydride / 1 h 4: hydrogen / methanol / 3.5 h / 20 °C / 18751.9 Torr / |Autoclave 5: dichloromethane / 2 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / |Reflux 2: ammonium acetate / |Heating 3: tin(IV) chloride / dichloromethane / -94 °C 4: trimethylsilyl bromide; triethylamine / acetonitrile / 18 h / -25 °C / |Inert atmosphere 5: silver nitrate / acetone; water / 3 h / |Reflux 6: acetic acid; zinc / 24 h 7: sodium cyanoborohydride / 1 h 8: hydrogen / methanol / 3.5 h / 20 °C / 18751.9 Torr / |Autoclave 9: dichloromethane / 2 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
1: ammonium acetate / |Heating 2: tin(IV) chloride / dichloromethane / -94 °C 3: trimethylsilyl bromide; triethylamine / acetonitrile / 18 h / -25 °C / |Inert atmosphere 4: silver nitrate / acetone; water / 3 h / |Reflux 5: acetic acid; zinc / 24 h 6: sodium cyanoborohydride / 1 h 7: hydrogen / methanol / 3.5 h / 20 °C / 18751.9 Torr / |Autoclave 8: dichloromethane / 2 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
1: tin(IV) chloride / dichloromethane / -94 °C 2: trimethylsilyl bromide; triethylamine / acetonitrile / 18 h / -25 °C / |Inert atmosphere 3: silver nitrate / acetone; water / 3 h / |Reflux 4: acetic acid; zinc / 24 h 5: sodium cyanoborohydride / 1 h 6: hydrogen / methanol / 3.5 h / 20 °C / 18751.9 Torr / |Autoclave 7: dichloromethane / 2 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
4 A molecular sieve; chiral diamine; triethylamine in dichloromethane T=-78°C; 3 h;
参考文献
Chemistry Letters, , # 3 p. 265 - 266
反应条件
1: 79 percent / CuCl / tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 5, # 2 p. 223 - 234
反应条件
triethylamine in toluene T=20°C; 16 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Chemistry - A European Journal, , vol. 15, # 23 p. 5669 - 5673
反应条件
1: (+/-)-trans-2-phenyl-1-cyclohexanol With (S)-(2-((dimethylamino)diphenylmethyl)pyrrolidin-1-yl)(4-(pyrrolidin-1-yl)pyridin-3-yl)methanone in dichloromethane T=-30°C; 0.5 h; Inert atmosphere; 2: acetic anhydride in dichloromethane T=-30°C; Inert atmosphere;
参考文献
Synlett, , vol. 24, # 13 art. no. ST-2013-B0413-L, p. 1728 - 1734
