(1R,2S)-(-)-反-2-苯基-1-环己醇合成路线 （共 53 条）
反应条件
1.1: trimethylsilyl bromide; triethylamine / acetonitrile / 18 h / -25 °C / |Inert atmosphere 2.1: sodium iodide; sodium azide / acetone; water / 24 h / 20 °C 3.1: sodium cyanoborohydride; acetic acid / 1.67 h / |Inert atmosphere 4.1: hydrogen / methanol / 5.5 h / 70 - 75 °C / 30003 Torr / |Autoclave 4.2: 0.5 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
1.1: sodium iodide; sodium azide / acetone; water / 24 h / 20 °C 2.1: sodium cyanoborohydride; acetic acid / 1.67 h / |Inert atmosphere 3.1: hydrogen / methanol / 5.5 h / 70 - 75 °C / 30003 Torr / |Autoclave 3.2: 0.5 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
Pseudomonas fluorescens lipase AK in various solvent(s) T=35°C; 120 h; Product distribution; Further Variations:Reagentstime;
参考文献
Synthesis, , # 5 art. no. F14904SS, p. 749 - 752
反应条件
1: (+/-)-trans-2-phenyl-1-cyclohexanol With (S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(diphenyl(1-(4-(pyrrolidin-1-yl)nicotinoyl)pyrrolidin-2-yl)methyl)urea in dichloromethane T=-30°C; 0.5 h; Inert atmosphere; 2: benzoic acid anhydride in dichloromethane T=-30°C; Inert atmosphere;
参考文献
Synlett, , vol. 24, # 13 art. no. ST-2013-B0413-L, p. 1728 - 1734
反应条件
in dichloromethane T=20°C; 2 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 46 p. 8082 - 8091
反应条件
IpcBH2 Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 45, # 17 p. 3543 - 3544
反应条件
1.1: potassium tert-butylate / dimethyl sulfoxide / 0 - 20 °C / |Inert atmosphere 1.2: 4 h / 60 °C / |Inert atmosphere 2.1: dihydrogen peroxide / water; dichloromethane / 1.08 h / 20 °C / |Inert atmosphere; |Cooling with ice 3.1: tin(IV) chloride / dichloromethane / 12 h / -65 °C / |Inert atmosphere 4.1: diisobutylaluminium hydride / toluene / -78 - 0 °C / |Inert atmosphere View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 1 p. 23 - 36
反应条件
1: tin(IV) chloride / dichloromethane / 12 h / -65 °C / |Inert atmosphere 2: diisobutylaluminium hydride / toluene / -78 - 0 °C / |Inert atmosphere View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 1 p. 23 - 36
反应条件
BF3*Bu2O; (1R,2R)-1,2-diphenyl-1,2-dimethoxyethane in diethyl ether; cyclohexane T=-78°C; 0.583333 h; enantioselective opening of oxirane, other educts, other reagents, solvent effect; Product distribution;
参考文献
Tetrahedron, , vol. 53, # 31 p. 10699 - 10708
反应条件
n-butyllithium; boron trifluoride diethyl etherate; (-)-sparteine in diethyl ether; hexane T=-78°C; Product distribution; Further Variations:Reagents;
参考文献
Tetrahedron, , vol. 60, # 42 p. 9479 - 9484
