2,3-二氢-1,4-苯并二噁英-6-碳酰肼合成路线 (共 5 条)
反应条件
hydrazine hydrate in ethanol
48 h; Reflux;
参考文献
Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Brodrecht, Martin; Pilakowski, Johannes; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris
European Journal of Medicinal Chemistry, 2013 , vol. 61, p. 26 - 40
反应条件
hydrazine hydrate in ethanol
24 h; Reflux;
参考文献
Yan, Ru; Zhang, Zhi-Ming; Fang, Xian-Ying; Hu, Yang; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 4 p. 1373 - 1379
参考文献
Hoffmann-La Roche Inc.
Patent: US6265426 B1, 2001 ;
US 6265426 B1
反应条件
1: potassium hydroxide; ethanol
2: ethanol; hydrazine hydrate
View Scheme
参考文献
Lipp et al.
Chemische Berichte, 1958 , vol. 91, p. 2239,2241,2245
反应条件
1: sulfuric acid / 8 h / 90 °C
2: potassium carbonate / acetone / 24 h / 70 °C / |Inert atmosphere
3: NH2NH2•xH2O / ethanol / 120 h / 90 °C
View Scheme
参考文献
Sun, Juan; Li, Ming-Hui; Qian, Shao-Song; Guo, Feng-Jiao; Dang, Xiao-Fang; Wang, Xiao-Ming; Xue, Ya-Rong; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2876 - 2879