2-(乙酰氨基)-4-吡啶羧酸甲酯合成路线 （共 6 条）
参考文献
Ferrari; Marcon
Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 485,487
反应条件
1: concentrated aqueous NH3 2: concentrated aqueous NH3 / 130 °C View Scheme
参考文献
Farmaco, Edizione Scientifica, , vol. 13, p. 485,487
反应条件
hydrogenchloride in methanol; chloroform
参考文献
SmithKline Beecham Corporation
Patent: US6403578 B1, 2002 ;
反应条件
in acetic acid
1 h; Reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; FINK, Brian; CHEN, Libing; GAVAI, Ashvinikumar; HE, Liqi; KIM, Soong-Hoon; NATION, Andrew; ZHAO, Yufen; ZHANG, Litai
Patent: WO2010/42699 A1, 2010 ;
Location in patent: Page/Page column 95 ;
WO 2010/042699 A1
反应条件
1: KMnO4; H2O
2: methanol. HCl
3: acetic acid
View Scheme
参考文献
Ferrari; Marcon
Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 485,487
反应条件
1: thionyl chloride / 13 h / 0 - 50 °C / |Inert atmosphere
2: 6 h / 80 °C / |Inert atmosphere
View Scheme
参考文献
Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Brodrecht, Martin; Pilakowski, Johannes; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris
European Journal of Medicinal Chemistry, 2013 , vol. 61, p. 26 - 40
