sodium hydroxide; water in methanol Hydrolysis; Heating;

1: With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane T=-78°C; Metallation; 1 h; 2: With iodine in tetrahydrofuran; hexane T=-78°C; Iodination; 1 h; Further stages.;

2.1: tetramethylethylenediamine; n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 76 percent / I2 / tetrahydrofuran; hexane / 1 h / -78 °C View Scheme

2.1: tetramethylethylenediamine; n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 2.2: 76 percent / I2 / tetrahydrofuran; hexane / 1 h / -78 °C View Scheme