1-Boc-4-氧-3-哌啶羧酸乙酯合成路线 （共 16 条）
反应条件
1: H2 / Ra-Ni / ethanol 2: Et3N / tetrahydrofuran 3: DBU / tetrahydrofuran 4: 98 percent / NaOH / H2O; methanol / 15 h / 20 °C View Scheme
参考文献
Knapp; Zhao
Organic letters, 2000 , vol. 2, # 25 p. 4037 - 4040
反应条件
hydrazine hydrate in ethanol; water 70 deg C, 3 h; r.t., 12 h;
参考文献
Moreno-Manas, Marcial; Perez, Montserrat; Pleixats, Roser
Tetrahedron, 1991 , vol. 50, # 2 p. 515 - 528
反应条件
1: 4-oxo-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester With trifluoroacetic acid in dichloromethane T=5 - 10°C; 2: benzyl chloroformate With triethylamine in dichloromethane T=0 - 20°C;
参考文献
PFIZER INC.; NINKOVIC, Sacha; BRAGANZA, John Frederick; COLLINS, Michael Raymond; KATH, John Charles; LI, Hui; RICHTER, Daniel Tyler
Patent: WO2010/16005 A1, 2010 ;
Location in patent: Page/Page column 95-96 ;
WO 2010/016005 A1
反应条件
1: H2 / Ra-Ni / ethanol 2: Et3N / tetrahydrofuran 3: DBU / tetrahydrofuran View Scheme
参考文献
Organic letters, , vol. 2, # 25 p. 4037 - 4040
反应条件
ethanol; ammonium acetate; sodium cyanoborohydride
2 h; Heating / reflux;
参考文献
Berthel, Steven Joseph; Erickson, Shawn David; Fotouhi, Nader; Kester, Robert Francis; Kim, Kyungjin; Mischke, Steven Gregory; Qian, Yimin; Thakkar, Kshitij Chhabilbhai; Tilley, Jefferson Wright; Wang, Hong
Patent: US2007/78165 A1, 2007 ;
Location in patent: Page/Page column 9 ;
US 20070078165 A1
反应条件
ammonium acetate in ethanol
T=20°C; 2.5 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.; Sumitomo Chemical Company, Limited
Patent: EP2078719 A1, 2009 ;
Location in patent: Page/Page column 20 ;
