1-boc-4-氧代-3-氮杂烷羧酸乙酯合成路线 （共 4 条）
反应条件
hydrogenchloride in water T=140°C; 8 h;
参考文献
SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell
Patent: WO2010/114971 A1, 2010 ;
Location in patent: Page/Page column 156 ;
反应条件
boron trifluoride diethyl etherate in diethyl ether
T=-30 - 20°C;
参考文献
SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell
Patent: WO2010/114971 A1, 2010 ;
Location in patent: Page/Page column 155-156 ;
反应条件
boron trifluoride diethyl etherate in diethyl ether
T=0°C; 1.5 h;
参考文献
JANSSEN PHARMACEUTICA NV; CARRUTHERS, Nicholas, I.; MACDONALD, Gregor, J.; SHIREMAN, Brock, T.; TRAN, Vi, T.
Patent: WO2010/53825 A1, 2010 ;
Location in patent: Page/Page column 32-33 ;
WO 2010/053825 A1
反应条件
1: triethylamine / tetrahydrofuran / 2 h / 0 °C
2: boron trifluoride etherate / diethyl ether / 0.5 h / -70 - -60 °C
View Scheme
参考文献
Brehm, Lotte; Krogsgaard-Larsen, Povl; Schaumburg, Kjeld; Johansen, Joergen S.; Falch, Erik; Curtis, David R.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 224 - 229
