(1H-苯并咪唑-2-甲基)甲胺合成路线 （共 6 条）
反应条件
potassium hydroxide in methanol
T=20°C; 0.5 h;
参考文献
SCHERING CORPORATION
Patent: EP1135374 B1, 2006 ;
Location in patent: Page/Page column 32 ;
反应条件
in chloroform
1) 10 h, rt, 2) 30 min, reflux; or in Et2O;
参考文献
Kaupp, Gerd; Sailer, Klaus
Angewandte Chemie, 1990 , vol. 102, # 8 p. 917 - 919
反应条件
in water; methylamine
参考文献
American Home Products Corporation
Patent: US5104892 A1, 1992 ;
反应条件
sodium acetate; sodium cyanoborohydride in isopropyl alcohol
72 h; Ambient temperature;
参考文献
Kempf, Dale J.; Codacovi, Lynnmarie; Wang, Xiu Chun; Kohlbrenner, William E.; Wideburg, Norman E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 320 - 330
反应条件
1: aqueous HCl
View Scheme
参考文献
Bloom; Day
Journal of Organic Chemistry, 1939 , vol. 4, p. 14,17
反应条件
1: water / 1.5 h / |Reflux
2: ethanol / 4 h / |Reflux
View Scheme
参考文献
Ansari; Lal; Parmar
Synthetic Communications, 2012 , vol. 42, # 24 p. 3553 - 3568
