反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
2.1: 5 Pd(II)/C(eggshell); hydrogen / methanol / 16 h
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Inert atmosphere; Cooling with ice
3.2: 18 h / Inert atmosphere
View Scheme
参考文献
Dockendorff, Chris; Aisiku, Omozuanvbo; Verplank, Lynn; Dilks, James R.; Smith, Daniel A.; Gunnink, Susanna F.; Dowal, Louisa; Negri, Joseph; Palmer, Michelle; MacPherson, Lawrence; Schreiber, Stuart L.; Flaumenhaft, Robert
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 3 p. 232 - 237