1: potassium carbonate / N,N-dimethyl-formamide / 96 h / |Reflux
2: diisobutylaluminium hydride / toluene / 0.75 h / -78 °C
View Scheme
参考文献
St. John, Sarah E.; Jensen, Katherine C.; Kang, Soosung; Chen, Yafang; Calamini, Barbara; Mesecar, Andrew D.; Lipton, Mark A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 19 p. 6022 - 6037
1: potassium carbonate / N,N-dimethyl-formamide / 96 h / |Reflux
2: diisobutylaluminium hydride / toluene / 0.75 h / -78 °C
View Scheme
参考文献
St. John, Sarah E.; Jensen, Katherine C.; Kang, Soosung; Chen, Yafang; Calamini, Barbara; Mesecar, Andrew D.; Lipton, Mark A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 19 p. 6022 - 6037
1: 84 percent / sodium hydroxide / heating
5: 28.8 g / fluoroboric acid, sodium nitrite / H2O
6: 7.6 g / warming, distillation
7: 1.) lithium / 1.) ether, 2 h
8: Cu-quinoline
9: boron tribromide, pyridine hydrochloride / CH2Cl2 / 24 h / -78 °C
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666