2-氨基-4-硝基甲苯合成路线 （共 108 条）
反应条件
sulfuric acid; water; sodium nitrite Diazotization;
参考文献
Witt; Noelting; Grandmougin
Chemische Berichte, 1890 , vol. 23, p. 3642
Chemische Berichte, 1892 , vol. 25, p. 3152
Full Text Show Details
Noelting; Collin
Chemische Berichte, 1884 , vol. 17, p. 265
反应条件
mineral acid Diazotization.Erwaermen der Reaktions-Loesung mit Natriumacetat;
参考文献
Noelting
Chemische Berichte, 1904 , vol. 37, p. 2583
参考文献
Witt; Noelting; Grandmougin
Chemische Berichte, 1890 , vol. 23, p. 3642
Chemische Berichte, 1892 , vol. 25, p. 3152
Full Text Show Details
Noelting; Collin
Chemische Berichte, 1884 , vol. 17, p. 265
反应条件
1: nBuONO / benzene 2: H2 / Raney-Ni / ethanol 3: benzene View Scheme
参考文献
Henry,D.W.
Journal of Heterocyclic Chemistry, 1966 , vol. 3, p. 503 - 511
反应条件
in butan-1-ol T=90 - 95°C; 4 h; Large scale;
参考文献
NATCO PHARMA LIMITED; KOMPELLA, Amala Kishan; RACHAKONDA, Sreenivas; GAMPA, Venu Gopala Krishna; ADIBHATLA, Kali Satya Bhujanga Rao; NANNAPANENI, Venkaiah Chowdary
Patent: WO2013/35102 A1, 2013 ;
Location in patent: Page/Page column 21 ;
反应条件
1.1: nitric acid / ethanol / 25 - 50 °C 1.2: 3 h / Reflux 2.1: sodium hydroxide / water View Scheme
参考文献
IND-SWIFT LABORATORIES LIMITED; AGGARWAL, Ashvin, Kumar; JAIN, Anshul, Kumar; BHIRUD, Shekhar, Bhaskar; WADHWA, Lalit
Patent: WO2011/39782 A1, 2011 ;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/110452 A1, 2004 ;
Location in patent: Page/Page column 24 ;
WO 2004/110452 A1
反应条件
1: 80 percent / phosphorus oxychloride / 2 h / heated on a steam bath 2: 1) potassium tert-butoxide, 2) acetic acid / 1) DMF, 45 min, on a steam bath, 2) H2O, 10 min, reflux 3: 96 percent / potassium hydroxide / ethanol; H2O / 1.5 h / Heating 4: 80 percent / quinoline / 185 °C View Scheme
参考文献
Bergman, Jan; Sand, Peter
Tetrahedron, 1990 , vol. 46, # 17 p. 6085 - 6112
反应条件
hydrogenchloride Diazotization.Kochen der Diazoniumsalz-Loesung mit CuCl;
参考文献
Journal of the Society of Chemical Industry, London, , vol. 55, p. 54 T
反应条件
Diazotization.Behandlung der neutralisierten Diazoniumsalz-Loesung mit NaNO2 in Gegenwart von CuSO4 und Cu2O in der Waerme;
参考文献
Hodgson; Heyworth
Journal of the Chemical Society, 1949 , p. 1624
Full Text Show Details
Hodgson; Heyworth; Ward
Journal of the Chemical Society, 1948 , p. 1512
