2-氨基-4-硝基甲苯合成路线 （共 108 条）
反应条件
1: nBuONO / benzene 2: H2 / Raney-Ni / ethanol View Scheme
参考文献
Henry,D.W.
Journal of Heterocyclic Chemistry, 1966 , vol. 3, p. 503 - 511
参考文献
Dauphin,G. et al.
Bulletin de la Societe Chimique de France, 1967 , p. 3404 - 3410
参考文献
Morgan; Micklethwait
Journal of the Chemical Society, 1906 , vol. 89, p. 1294
反应条件
Diazotization.Kupplung der Diazoverbindung mit β-Naphtholdisulfonsaeure und Reduktion der hierbei entstandenen Azoverbindung mit Glykose, Zink, Zinn oder Formaldehyd in alkal.Loesung;
参考文献
Graeff
Justus Liebigs Annalen der Chemie, 1885 , vol. 229, p. 343
反应条件
weitere Einw. von Natriumamalgam in Alkohol auf das entstehende 3.3'-Diamino-4.4'-dimethyl-azoxybenzol;
参考文献
Limprich
Chemische Berichte, 1885 , vol. 18, p. 1405,1406
Full Text Show Details
Graeff
Justus Liebigs Annalen der Chemie, 1885 , vol. 229, p. 343
反应条件
1: 93 percent / sulfuric acid; sodium nitrite / H2O / 0.33 h / Heating 2: 46.0 g / potassium carbonate / acetone / 4 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 11 p. 2867 - 2879
反应条件
1: 87 percent / 1.) NaNO2; 2.) H2SO4 / H2O / Heating
2: 81 percent / KI, K2CO3 / acetonitrile / 48 h / 82 °C
3: 93 percent / o-xylene / 14 h / 140 °C
4: 79 percent / tin, hydrochloric acid / methanol / 80 °C
5: 1.) K2CO3; 2.) manganese dioxide / 1.) THF, 65 deg C, 12 h; 2.) CH2Cl2, 40 deg C, 24 h
View Scheme
参考文献
Knoelker, Hans-Joachim; Hofmann, Christoph
Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7947 - 7950
反应条件
sulfuric acid; 2,4,6-trinitro-phenol
T=160°C;
参考文献
Noelting; Trautmann
Chemische Berichte, 1890 , vol. 23, p. 3655
反应条件
in acetone
T=15 - 35°C; 4 h;
参考文献
AB SCIENCE
Patent: WO2008/98949 A2, 2008 ;
Location in patent: Page/Page column 18; 19 ;
WO 2008/098949 A2
反应条件
1: 84 percent / pyridine / CHCl3 / 6 h / 20 °C
2: 55.6 percent Turnov. / N-bromosuccinimide / CCl4 / 20 h / 20 °C / Photolysis
View Scheme
参考文献
Hu, Longqin; Yu, Chengzhi; Jiang, Yongying; Han, Jiye; Li, Zhuorong; Browne, Patrick; Race, Paul R.; Knox, Richard J.; Searle, Peter F.; Hyde, Eva I.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 4818 - 4821
