2-氨基-4-硝基苯酚合成路线 （共 142 条）
反应条件
bis-[(trifluoroacetoxy)iodo]benzene in ethanol
T=80°C; 0.25 h; Microwave irradiation;
参考文献
Praveen; Nandakumar; Dheenkumar; Muralidharan; Perumal
Journal of Chemical Sciences, 2012 , vol. 124, # 3 p. 609 - 624
参考文献
Bhagyasree; Varghese, Hema Tresa; Panicker, C. Yohannan; Samuel, Jadu; Van Alsenoy, Christian; Ertan-Bolelli, Tugba; Yildiz, Ilkay
Journal of Molecular Structure, 2014 , vol. 1063, # 1 p. 16 - 29
参考文献
Makosza, Mieczyslaw; Stalewski, Jacek
Tetrahedron, 1995 , vol. 51, # 26 p. 7277 - 7286
反应条件
1: ethanol / 1.3 h / Heating
2: Pb(OAc)4 / benzene / 0.5 h / Ambient temperature
View Scheme
参考文献
Yu, Peng; Zhang, Guangyou; Chen, Fan; Cheng, Jiang
Tetrahedron Letters, 2012 , vol. 53, # 34 p. 4588 - 4590
参考文献
Hoffmann-La Roche Inc.
Patent: US6153634 A1, 2000 ;
US 6153634 A
反应条件
ammonium chloride in ethanol
Inert atmosphereRefluxGreen chemistry;
参考文献
Fortenberry, Chelsea; Nammalwar, Baskar; Bunce, Richard A.
Organic Preparations and Procedures International, 2013 , vol. 45, # 1 p. 57 - 65
反应条件
in methanol
Heating;
参考文献
Lagutkin, N. A.; Mitin, N. I.; Zubairov, M. M.; Zelentsov, V. V.; Nikolaeva, T. B.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 2 p. 113 - 116
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 2 p. 178 - 181
反应条件
pyridine in dichloromethane
5 h; Ambient temperature;
参考文献
Bartsch, Richard A.; Robison, Thomas W.; Desai, Dhimant H.; Krzykawski, Jan; Dalley, N. Kent; Jiang, Weiming
Journal of Organic Chemistry, 1992 , vol. 57, # 5 p. 1625 - 1627
反应条件
1.1: sodium hydrogencarbonate / water / 0.5 h / 0 °C
1.2: |Reflux
2.1: borane-THF / tetrahydrofuran / 2 h / |Reflux
2.2: 1 h / |Reflux
3.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C
3.2: 2 h / 20 °C
4.1: palladium 10 on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 20 °C
View Scheme
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
反应条件
1.1: sodium hydrogencarbonate / water / 0.5 h / 0 °C
1.2: |Reflux
2.1: borane-THF / tetrahydrofuran / 2 h / |Reflux
2.2: 1 h / |Reflux
3.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C
3.2: 2 h / 20 °C
View Scheme
参考文献
Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3821 - 3830
