2-氨基-4-硝基苯酚合成路线 （共 142 条）
反应条件
1: aq. ethanol / 0.5 h / Ambient temperature
2: Pb(OAc)4 / acetonitrile / 0.08 h / Heating
3: H2 / PtO2 / ethanol / 2585.7 Torr
View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
反应条件
1: aq. ethanol / 0.5 h / Ambient temperature
2: Pb(OAc)4 / acetonitrile / 0.08 h / Heating
3: H2 / PtO2 / ethanol / 2585.7 Torr
4: triethylamine / tetrahydrofuran / 3 h / Ambient temperature
View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
反应条件
1: H2 / 10 percent Pd/C / methanol / 15 h / 760 Torr
View Scheme
参考文献
Sam,J.; Plampin,J.N.
Journal of Pharmaceutical Sciences, 1964 , vol. 53, p. 538 - 544
反应条件
potassium cyanide; 3,4,5-trimethoxyphenylboronic acid in methanol
T=20°C; 24 h; Inert atmosphere;
参考文献
Massue, Julien; Frath, Denis; Ulrich, Gilles; Retailleau, Pascal; Ziessel, Raymond
Organic Letters, 2012 , vol. 14, # 1 p. 230 - 233
反应条件
1: KOH / ethanol / Heating
2: PCl5 / toluene / Heating
View Scheme
参考文献
GALLEON PHARMACEUTICALS, INC.
Patent: US2011/224269 A1, 2011 ;
反应条件
sodium carbonate in chloroform
3 h; Ambient temperature;
参考文献
Caliendo, Giuseppe; Perissutti, Elisa; Santagada, Vincenzo; Fiorino, Ferdinando; Severino, Beatrice; Cirillo, Donatella; D'Emmanuele Di Villa Bianca, Roberta; Lippolis, Laura; Pinto, Aldo; Sorrentino, Raffaella
European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 815 - 826
反应条件
1: ethanol / 1.3 h / Heating
2: Pb(OAc)4 / benzene / 0.5 h / Ambient temperature
3: 91 percent / H2, AcOH / 10percent Pd/C / 1.5 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Gorla, Suresh Kumar; Kavitha, Mandapati; Zhang, Minjia; Chin, James En Wai; Liu, Xiaoping; Striepen, Boris; Makowska-Grzyska, Magdalena; Kim, Youngchang; Joachimiak, Andrzej; Hedstrom, Lizbeth; Cuny, Gregory D.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 4028 - 4043
反应条件
1: aq. ethanol / 0.5 h / Ambient temperature
2: Pb(OAc)4 / acetic acid / 2 h / Heating
3: H2 / PtO2 / ethanol / 2585.7 Torr
View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
反应条件
1: aq. ethanol / 0.5 h / Ambient temperature
2: Pb(OAc)4 / acetic acid / 2 h / Heating
3: H2 / PtO2 / ethanol / 2585.7 Torr
View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
反应条件
1: aq. ethanol / 0.5 h / Ambient temperature
2: Pb(OAc)4 / acetic acid / 2 h / Heating
3: H2 / PtO2 / ethanol / 2585.7 Torr
View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
