2-氨基-4-硝基苯酚合成路线 （共 142 条）
反应条件
1: NaNO2, aq. HBF4 2: (i) Na2S, sulfur, aq. NaOH, (ii) /BRN= 471308/, Na2CO3 View Scheme
参考文献
Focella,A. et al.
Canadian Journal of Chemistry, 1972 , vol. 50, p. 2025 - 2030
反应条件
sulfuric acid; water; orthoarsenic acid
参考文献
Vogt; Jeske
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 168,175
反应条件
in ethanol T=80°C; 3 h;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2005/245500 A1, 2005 ;
Location in patent: Page/Page column 31 ;
US 20050245500 A1
反应条件
sodium carbonate in N,N-dimethyl-formamide 5 h; Heating / reflux;
参考文献
Calvo, Raul R.; Cheung, Wing S.; Player, Mark R.
Patent: US2006/116368 A1, 2006 ;
Location in patent: Page/Page column 70; 71 ;
参考文献
Ortho Pharmaceutical Corporation
Patent: US5696117 A1, 1997 ;
US 5696117 A
反应条件
acetic acid in ethanol pH=5; 4.5 h; Reflux;
参考文献
Ongarora, Dennis S.B.; Gut, Jiri; Rosenthal, Philip J.; Masimirembwa, Collen M.; Chibale, Kelly
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5046 - 5050
反应条件
pyridine 1 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/66173 A2, 2006 ;
Location in patent: Page/Page column 47 ;
WO 2006/066173 A2
反应条件
1: With potassium carbonate in ethanol 2 h; Heating; 2: With dihydrogen peroxide in ethanol 1 h; Further stages.;
参考文献
Singh; Singh, Pallavi; Singh, Shweta
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2007 , vol. 46, # 10 p. 1666 - 1671
参考文献
Katz; Cohen
Journal of Organic Chemistry, 1954 , vol. 19, p. 758,762, 765
反应条件
TSA in neat (no solvent) T=80 - 90°C; 0.166667 h; Reagent/catalyst;
参考文献
Farahi, Mahnaz; Karami, Bahador; Azari, Masume
Comptes Rendus Chimie, 2013 , vol. 16, # 11 p. 1029 - 1034
