2-氨基-4-硝基苯酚合成路线 （共 142 条）
参考文献
Meldola; Woolcott; Wray
Journal of the Chemical Society, 1896 , vol. 69, p. 1323
反应条件
1: aqueous methanol. KOH 2: iron; concentrated aqueous HCl View Scheme
参考文献
Katz; Cohen
Journal of Organic Chemistry, 1954 , vol. 19, p. 758,762, 765
反应条件
1: acetic acid / ethanol / 4.5 h / pH 5 / Reflux 2: N,N-dimethyl-formamide / 4 h / 25 °C View Scheme
参考文献
Ongarora, Dennis S.B.; Gut, Jiri; Rosenthal, Philip J.; Masimirembwa, Collen M.; Chibale, Kelly
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5046 - 5050
反应条件
in methanol Heating;
参考文献
Chen, Chun-Jung; Wang, I-Wen; Sheu, Hwo-Shuenn; Lee, Gene-Hsiang; Lai, Chung K.
Tetrahedron, 2011 , vol. 67, # 42 p. 8120 - 8130
反应条件
1: arsenic acid; sulfuric acid; water 2: beim Behandeln mit Brom in Essigsaeure View Scheme
参考文献
Vogt; Jeske
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 168,175
反应条件
in toluene 8 h; Reflux;
参考文献
Ramirez-Jimenez, Alejandro; Luna-Garcia, Rolando; Cortes-Lozada, Armando; Hernandez, Simon; Ramirez-Apan, Teresa; Nieto-Camacho, Antonio; Gomez, Elizabeth
Journal of Organometallic Chemistry, 2013 , vol. 738, p. 10 - 19
反应条件
1: With sulfuric acid; sodium nitrite in dimethyl sulfoxide T=0°C; 2: With potassium iodide in dimethyl sulfoxide T=20°C;
参考文献
Dai, Wei-Min; Lai, Kwong Wah
Tetrahedron Letters, 2002 , vol. 43, # 51 p. 9377 - 9380
反应条件
potassium carbonate in N,N-dimethyl-formamide T=125°C; Inert atmosphere;
参考文献
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; CHIOSIS, Gabriela; TALDONE, Tony; SUN, Weilin
Patent: WO2011/44394 A1, 2011 ;
Location in patent: Page/Page column 117-118 ;
反应条件
1: 94 percent / HCOONa / 2.5 h / Heating 2: 42 percent / NaH / dimethylformamide / 1.) 20 deg C, 4 h, 2.) 120-140 deg C, 20 h 3: 78 percent / 1 N aq. HCl / 2.5 h / 100 °C View Scheme
参考文献
Petter, Russell C.; Jewell, Charles F.; Lee, Kwangho; Medikonda, Aravind Prasad; Niu, Deqiang; Qiao, Lixin; Singh, Juswinder; Zhu, Zhendong
Patent: US2011/269244 A1, 2011 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Schering Corporation and Pharmacopeia Drug Discovery, Inc.
Patent: US2007/93477 A1, 2007 ;
Location in patent: Page/Page column 20 ;
