2-氨基-4-硝基苯酚合成路线 （共 142 条）
反应条件
potassium fluoride in N,N-dimethyl-formamide T=160°C; 1 h; Microwave irradiation;
参考文献
Schering Corporation and Pharmacopeia Drug Discovery, Inc.
Patent: US2007/93477 A1, 2007 ;
Location in patent: Page/Page column 31 ;
反应条件
1: 82 percent / Et3N / tetrahydrofuran 2: 70 percent / potassium carbonate / dimethylformamide / 50 °C 3: 1.) BH3, 2.) methanol, 3.) conc. HCl View Scheme
参考文献
Matsumoto, Yuzo; Tsuzuki, Ryuji; Matsuhisa, Akira; Takayama, Kazuhisa; Yoden, Toru; Uchida, Wataru; Asano, Masaharu; Fujita, Shigeo; Yanagisawa, Isao; Fujikura, Takashi
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 103 - 114
反应条件
pyridine in tetrahydrofuran T=20°C; 16 h;
参考文献
Sun, Li-Ping; Huang, Xiang-Hong; Dai, Wei-Min
Tetrahedron, 2004 , vol. 60, # 48 p. 10983 - 10992
反应条件
pyridine; trifluoroacetic anhydride in diethyl ether; ethanol
参考文献
Synthelabo
Patent: US5550125 A1, 1996 ;
反应条件
1: 82 percent / Et3N / tetrahydrofuran 2: 70 percent / potassium carbonate / dimethylformamide / 50 °C 3: 1.) BH3, 2.) methanol, 3.) conc. HCl 4: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h View Scheme
参考文献
Matsumoto, Yuzo; Tsuzuki, Ryuji; Matsuhisa, Akira; Takayama, Kazuhisa; Yoden, Toru; Uchida, Wataru; Asano, Masaharu; Fujita, Shigeo; Yanagisawa, Isao; Fujikura, Takashi
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 103 - 114
反应条件
potassium fluoride in N,N-dimethyl-formamide cyclocondensation; 16 h;
参考文献
Matsumoto, Yuzo; Uchida, Wataru; Nakahara, Hideaki; Yanagisawa, Isao; Shibanuma, Tadao; Nohira, Hiroyuki
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 3 p. 428 - 432
反应条件
potassium fluoride in N,N-dimethyl-formamide T=60°C; 6 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 3 p. 597 - 602
反应条件
1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C / |Cooling with ice 2: hydrogen; palladium 10 on activated carbon / methanol / 20 °C View Scheme
参考文献
Xie, Yuanchao; Huang, Bing; Yu, Kexiang; Shi, Fangyuan; Liu, Tianqi; Xu, Wenfang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 12 p. 3556 - 3560
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 125 °C / Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C 2.2: 2 h / 20 °C View Scheme
参考文献
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; CHIOSIS, Gabriela; TALDONE, Tony; SUN, Weilin
Patent: WO2011/44394 A1, 2011 ;
反应条件
1: boric acid / anhydrous xylene / 24 h / Heating 2: 10 palladium on activated charcoal; hydrogen / ethanol; ethyl acetate View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 2 p. 543 - 545
