1: 3-chloro-propionaldehyde diethyl acetal With lithium; 4,4'-di-tert-butylbiphenyl in tetrahydrofuran
T=-78°C; 1 h;
2: With zinc dibromide in tetrahydrofuran
T=-78 - 20°C;
3: para-bromoacetophenone With Pd(OAc)2(PPh3)2 in tetrahydrofuran
T=70°C; Negishi cross-coupling reaction; Further stages.;
参考文献
Yus, Miguel; Gomis, Joaquin
European Journal of Organic Chemistry, 2002 , # 12 p. 1989 - 1995
1.1: trichlorophosphate / 0.25 h / 25 °C
1.2: 0.5 h / 20 - 60 °C
1.3: 0.5 h
2.1: sodium; methanol / 0.5 h / |Reflux
3.1: potassium hydroxide / methanol; water / 3 h / |Reflux
4.1: tetrahydrofuran; toluene / 2 h / 20 °C
View Scheme
参考文献
Sahner, J. Henning; Brengel, Christian; Storz, Michael P.; Groh, Matthias; Plaza, Alberto; Mueller, Rolf; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8656 - 8664
