1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 15 - 38 °C / |Inert atmosphere
2.1: sodium nitrite / tetrahydrofuran; acetic acid; water / 3 h / 6 - 9 °C / |Large scale
3.1: zinc / acetic acid; water; ethanol / 2.25 h / -5 - 20 °C / |Inert atmosphere
3.2: 16 h / -9 - 20 °C
4.1: potassium carbonate / water; acetone / 4.2 h / 30 - 34.1 °C / |Inert atmosphere
View Scheme
参考文献
Magnus, Nicholas A.; Staszak, Michael A.; Udodong, Uko E.; Wepsiec, James P.
Organic Process Research and Development, 2006 , vol. 10, # 5 p. 899 - 904
1: 86 percent / 1,1,1,3,3,3-hexamethyldisilazane; acetic acid / 65 °C
2: 73 percent / S8; NaHCO3 / tetrahydrofuran; H2O / 1.5 h / 35 °C
View Scheme
参考文献
Barnes, David M.; Haight, Anthony R.; Hameury, Thomas; McLaughlin, Maureen A.; Mei, Jianzhang; Tedrow, Jason S.; Riva Toma, Joan Dalla
Tetrahedron, 2006 , vol. 62, # 49 p. 11311 - 11319
Litvinenko, L. M.; Benndorf, V.; Popova, R. S.; Popov, A. F.; Tormosin, I. I.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 4 p. 680 - 683
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 4 p. 772 - 775